Tristetraprolin (TTP) Expression Is Required For Maintenance of the Mammary Progenitor Cell Population

STEDILE, MICAELA; BECKERMAN, INÉS; GODDIO, MARÍA VICTORIA; PÉREZ CUERVO, LOURDES; GARCÍA SOLÁ, MARTÍN; MEDINA, MARÍA VIRGINIA; RAIMONDI, ANA; COSO, OMAR; KORDON, EDITH CLAUDIA

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias 2019; 2019

Sociedad Argentina de Investigación Clínica (SAIC)

Messenger RNA (mRNA) stability is regulated mainly by proteins that bind sequences enriched in adenine and uracil in their 3´untranslated regions, called AU-binding proteins (AUBPs). Tristetraprolin (TTP) is an AUBP that promotes mRNA degradation of proteins involved in inflammation, proliferation and tumor invasiveness. In particular, RNA-seq data indicates that TTP is up-regulated in mammary progenitor cells (p