BECAS
RIVABELLA MAKNIS Tomas
congresos y reuniones científicas
Título:
RENAL EXPRESSION OF RhoGTPases AND ITS MODULATOR, ICMT, IN THE EVOLUTION OF TUBULAR EPITHELIAL RESPONSE TO ACUTE RENAL DAMAGE
Autor/es:
BUONO, GABRIEL M.; FUSSI, MARÍA F. ; MARQUEZ, SUSANA B.; RIVABELLA MAKNIS, TOMAS; GIRARDINI, JAVIER E.; LAROCCA, M. CECILIA; MONASTEROLO, LILIANA A.; MOLINAS, SARA M.
Lugar:
Rosario
Reunión:
Congreso; REUNIÓN ANUAL SAFIS 2019; 2019
Institución organizadora:
Sociedad Argentina de Fisiología (SAFIS)
Resumen:
Acute kidney injury (AKI) is still a significant medical problem. Renal ischemiareperfusion (IR) injury is one of the main causes of AKI. RhoA and Cdc42 are RhoGTPasesinvolved in the maintenance of epithelial integrity in renal tubules. Our aim was to study thesignaling pathways involved in the development of AKI by characterizing RhoGTPasepathway in the IR model. Male Wistar rats (n=6 per group) were subjected to 40 min ofunilateral renal ischemia followed by 1 (I1) or 7 (I7) days of reperfusion, or sham operation.Histological studies showed extensive tubular damage in I1 kidneys associated withdecreased glomerular filtration rate (GFR). In agreement with studies performed at shorterreperfusion times, we found that cortical expression of RhoA (-65% p
