Understanding the mechanism of silver nanoparticle toxicity

GARCÉS, MARIANA; MAGNANI, NATALIA; CALABRO, VALERIA; MARCHINI, TIMOTEO; CACERES, LOURDES; SALGUEIRO, JIMENA; GALDOPORPORA, JUAN; ZUBILLAGA, MARCELA; MORETTON, MARCELA; DESIMONE, MARTIN; PECORELLI, ALESSANDRA; ALVAREZ, SILVIA; VALACCHI, GIUSEPPE; EVELSON, PABLO

Ferrara

Congreso; 2019 Annual Meeting: Redox Homeostasis: from Signaling to Damage; 2019

Society for Free Radical Research-Europe

The development of silver nanoparticles (AgNP) applications increased the concern about their toxicity. As the respiratory system in one of the exposure routes, the aim of this study was to evaluate the AgNP harmful effects developed in lung. AgNP were able to cleave H2O2 leading to OH production. In A549 cells exposed to 2.5 μg/mL AgNP a decreased mitochondrial basal and maximal respiration (p