IMPLICATIONS OF THYROID HORMONES (TH) IN REXINOIDS ANTI-LYMPHOMA ACTIVITY: INTEGRIN ALPHA V BETA 3 INHIBITION IN THE TREATMENT OF T CELL LYMPHOMA (TCL) WITH BEXAROTENE

DEBERNARDI, M; DÍAZ ALBUJA, J.A.; STERLE, H.A.; DÍAZ FLAQUÉ, M. CELESTE; CREMASCHI, G.A.; CAYROL, FLORENCIA

Congreso; ANNUAL MEETING OF BIOSCIENCE SOCIETIES 2019; 2019

Bexarotene (Bex), a RXR agonist used forcutaneous TLC treatment, is associated with clinicalhypothyroidism, thus requiring the concomitant administration oflevothyroxine (T4). We found that physiological levels of THcontribute to the malignant phenotype of TCL via the THmembrane receptor (mTR), the integrin alphaVbeta3. Here weinvestigated the consequence of T4 on the antineoplastic effectof Bex in different TCL subtypes. We confirm the presence of theRXR by WB in our panel of TCL subtypes. BEx effect in vitro onapoptosis and proliferation of CUTLL1, OCI-Ly12 and OCI- Ly13.2TCL cells was higher in the absence than in the presence of THsupplementation (p