INVESTIGADORES
LACOSTE Maria Gabriela
congresos y reuniones científicas
Título:
DEFICIENCY OF TUMOR NECROSIS FACTOR p55 RECEPTOR ENHANCES INTERFERON-GAMMA AND INTERLEUKIN-17 RESPONSES AFTER Yersinia INFECTION
Autor/es:
CARGNELUTTI, ETHELINA; ELIÇABE, JAVIER; LACOSTE, MARÍA GABRIELA; RABINOVICH, GABRIEL ADRIÁN; DI GENARO, MARÍA SILVIA
Lugar:
Viña del Mar
Reunión:
Congreso; 9th Latin American Congress of Immunology; 2009
Institución organizadora:
Latin American Association of Immunology - SOCHIN - SAI
Resumen:
We previously demonstrated that Yersinia induces reactive arthritis in TNFRp55-/-mice. The aim was elucidate the impact of TNFRp55 deficiency on IFN-gamma and IL-17 responses. Wild-type C57BL/6 (WT) and TNFRp55-/- mice were orogastrically infected with Yersinia enterocolitica O:3. At different days after infection, IL-17, IFN-gamma, IL-6, TGF-beta and p40 subunit were determined in mesenteric lymph nodes (MLN) and inguinal lymph nodes (ILN) homogenates by ELISA. In addition, adoptive transfer of T cells was performed from Yersinia-infected TNFRp55-/- to naive WT, TNFRp55-/- or p40-/- mice; then, these mice were challenged with heat-killed Yersinia (HKY) and delayed-type hypersensitivity (DTH) was determined. We found higher IL-17 and IFN-gamma levels in TNFRp55-/- compared with WT mice in MLN (p< 0.001 and p
