CONICET | Buscador de Institutos y Recursos Humanos

Prenatal Stress has been associated with changes in immune response but the mechanism involved has not been fully elucidated. Over the last years considerable evidence showed a dynamic interaction between the brain and the immune system. The aim of this work was investigate alterations in neuroimmune interaction in adults animals subjected to PS. For this purpose, pregnant mice were individually restrained 2 hour a day, since gestational day 14, until delivery. Stressed offspring mice were tested at 2-months of age together with control matched mice. A group of animals were submitted to acute or chronic stress. Results shown that PS was not induce significant changes in proliferative response, corticosterona or catecholamines levels. However, these animals have a lower proliferative response respect to control mice when were submitted to acute and chronic stress. Moreover, PS animals respond to acute stress with lower levels of corticosterone. But, not significant changes were observed under chronic stress. On the other hand, PS animals respond to both acute and chronic stress with a similar changes of catecholamines levels than control animals. In addition an increased sensitivity of inhibitory effect of corticosterona were found in lymphocytes from PS animals. These results indicate that PS induce a disruption in hyphotalamic-pituitary-adrenal axis (HPA)- immune interaction.