XYLAN BASED HYDROGELS FOR CONTROLLED DRUG RELEASE STUDIES

CARLA N. SCHNELL; MARÍA V. GALVÁN; MIGUEL A. ZANUTTINI; PAULINA MOCCHIUTTI

Sao Pablo

Congreso; 51st Pulp and Paper International Congress & Exhibiton ABTCP - X Iberoamerican Congress on pulp and Paper Research CIADICyP (2018).; 2018

ABTCP, CIADICyP

In this work, hydrogels from colloidal suspensions of polyelectrolyte complexes (PECs) of xylan (Xyl) and chitosan (Ch) (70 wt% Xyl / 30 wt% Ch) were prepared and ionic crosslinked by sodium citrate solutions (3%, 5% and 7% w/v). Hydrogels were characterized by means of mechanical properties, swelling and solubility. The ability of these hydrogels as a system for controlled drug release was studied in vitro using diclofenac sodium (DS) as a model drug. It was found that with increasing the amount of sodium citrate, the mechanical properties of the hydrogels were increased. Crosslinked hydrogels showed about 130% higher wet-stress at break, and 75% higher wet-strain at break than non-crosslinked hydrogels. The swelling of non-crosslinked hydrogels in PBS (phosphate buffer saline) at pH 7.4 after 24 h was up to 220%. With increasing the amount of crosslinking agent (from 3% to 7%), the swelling results decreased. The drug loading process was made by immersing the hydrogels in sodium diclofenac solutions for 20 h and at pH 7.4. Drug release process was made in PBS medium at pH 7.4 and 37ºC. Compared to non-crosslinked hydrogels, the crosslinked ones absorbed significantly higher amounts of sodium diclofenac, and released it in a more controlled way. Results suggest that these biodegradable hydrogels have potential application as drug delivery system.