Role of angiotensin II type 2 receptor (AT2R) in the evolution of the tubular epithelial response to acute kidney injury. Use of AT2R agonist, Compound 21, as a therapeutic strategy.

FUSSI M. FERNANDA; MARQUEZ SUSANA; BUONO GABRIEL; MOLINAS, JORGE; TRUMPER, LAURA; LILIANA A. MONASTEROLO; MOLINAS, SARA M.

Rosario

Congreso; XX Congreso de la Sociedad de Biología de Rosario; 2018

Sociedad de Biología de Rosario

ROLE OF THE ANGIOTENSIN II TYPE 2 RECEPTOR (AT2R) IN THE EVOLUTION OF THE TUBULAR EPITHELIAL RESPONSE TO ACUTE KIDNEY INJURY. USE OF AT2R AGONIST, COMPOUND 21, AS A THERAPEUTIC STRATEGY.Ischemia-reperfusion (IR) is the main cause of acute kidney injury (AKI). The epithelial-mesenchymal transition (TEM) is a key process in the pathogenesis of AKI. Via AT2R receptor, angiotensin II, promotes vasodilatory, anti-inflammatory and antifibrotic actions and participates in tissue repair. Its role in renal IR is not known. Our aim was to characterize the evolution of renal IR damage and to study the effects of pre-treatment with C21, an AT2R agonist. Male Wistar rats (n=6 per group) were subjected to 40 min of unilateral renal ischemia followed by 1 (I1) or 7 (I7) days of reperfusion. Controls underwent sham operation. Glomerular filtration rate (GFR) was reduced in I1 (-50%, p