MULTIVARIATE ANALYSIS OF IMMUNE CELLS POPULATIONS INVOLVED IN TUMOR GROWTH

DEL GIÚDICE ANTONELA; CAPITANI M. CELESTE; FUSINI MATÍAS E.; MAINETTI LEANDRO E.; SCHAROVSKY OLGA GRACIELA; DI MASSO RICARDO JOSÉ; RICO MARÍA JOSÉ; ROZADOS VIVIANA R.

Mar del Plata

Congreso; LXIII Reunión Científica Anual, Soc Arg. de Investigación Clínica; 2018

M-406 mammary adenocarcinoma appeared in an inbred CBi mouse. CBi- mice were artificially selected by body conformation from CBi. When CBi- mice are s.c. challenged with M-406, 100% of the tumors are rejected; conversely, tumor grows exponentially in CBi. To explain the participation of the immune system in this behavior, CBi and CBi- females (N=9), were inoculated with M-406, blood samples were taken on days 0, 7 and 14, and CD4+, CD8+, Treg and Th17 cells were quantified (flow cytometry). Day 0- CD4+: CBiCBi- (P=0.0041), Treg: CBi>CBi- (P=0.0003) and Th17: CBi