INVESTIGADORES
DICKENSTEIN Alicia Marcela
congresos y reuniones científicas
Título:
Algebra and geometry in the study of enzymatic cascades
Autor/es:
A, DICKENSTEIN
Lugar:
Rio de Janeiro
Reunión:
Congreso; World Meeting of Women Mathematicians; 2018
Institución organizadora:
CWM, International Mathematical Union
Resumen:
In recent years, techniques from computational and real algebraic geometry have been successfully used to address mathematical challenges in systems biology. The algebraic theory of chemical reaction systems aims to understand their dynamic behavior by taking advantage of the inherent algebraic structure in the kinetic equations, and does not need a priori determination of the parameters, which can be theoretically or practically impossible.I will give a gentle introduction to general results based on the network structure. In particular, I will describe a general framework for biological systems, called MESSI systems, that describe Modifications of type Enzyme-Substrate or Swap with Intermediates, and include many post-translational modication networks. I will also outline recent methods to address the important question of multistationarity, in particular in the study of enzymatic cascades, and will point out some of the mathematical challenges that arise from this application.