THE THYROID STATUS REGULATES TRIPLE NEGATIVE BREAST CANCER (TNBC) GROWTH AND METASTASIS THROUGH THE MODULATION OF MESENCHYMAL STROMAL CELL (MSC) MIGRATION AND ANTITUMOR IMMUNE RESPONSE

STERLE HA; HILDEBRANDT X; GUTIERREZ L; PAULAZO MA; CAYROL F; DÍAZ FLAQUÉ MC; ROSEMBLIT C; BOLONTRADE M; CREMASCHI GA

Mar del Plata

Congreso; Reunión Conjunta SAIC SAI SAFIS 2018; 2018

The association between thyroid disease and breast cancer riskremains unclear. Our aim was to evaluate the effect of thyroidstatus on TNBC development. For this, Balb/c mice were orthotopicallyinoculated with 4T1 cells after the treatment with thyroxine(12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in thedrinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo)mice, respectively. An increased tumor growth rate, that becameevident at day 21 post-inoculation (p.i.), was seen in hyper micecompared to controls (p