THE IL-10/STAT3/SOCS3 AXIS IS INVOLVED IN THE ANTI-INFLAMMATORY EFFECT OF BENZNIDAZOLE

ÁGATA CAROLINA CEVEY; FEDERICO NICOLÁS PENAS; CATALINA ALBA SOTO,; , GERARDO ARIEL MIRKIN; GOREN, NORA

Mar del Plata

Congreso; Reunión Anual SAIC SAI SAFIS; 2018

SAIC SAI SAFIS

Chagas disease is the main cause of dilated cardiomyopathyin Latin America. During the acute infection, theinflammatory response is critical for the control of parasiteproliferation and its evolution. Benznidazole (Bz),one of the anti-parasitic drugs currently used for its treatment,exerts anti-inflammatory effects. We showed previouslythat a low dose of Bz reduces the expression ofinflammatory mediators through the inhibition of the NF-κB pathway, although the mechanism involved is poorlyunderstood. In order to clarify, and to separate the anti-inflammatory effects from its anti-parasitic properties,mouse neonatal cardiomyocytes were stimulated with10 μg/ml of LPS. The pre-treatment with 15 μM Bz increasedSOCS3 expression (RT-qPCR) (p