IFEC   20925
INSTITUTO DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
AT1 receptors are essential players in the development of amphetamine-induced inflammation in prefrontal cortex: relevance for neuroinflammatory pathologies
Autor/es:
OCCHIEPO V; MARCHESE NA; BREGONZIO C; BASMADJIAN M
Lugar:
Cordoba
Reunión:
Congreso; SAN 2018; 2018
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Amphetamines are related to brain vascular damage, neuroinflammation, working memory deficit and prefrontal cortex (PFC) hypo-function. Brain angiotensin II, through AT1 receptors (AT1-R), modulates catecholamine neurotransmission and is involved in psychostimulants-induced neuroadaptations. Furthermore, these receptors are key mediators in neuroinflammatory responses by promoting endothelial dysfunction, neuronal oxidative damage and astrocyte and microglial reactivity.Objectives. The present work aimed to elucidate amphetamine-induced changes in the cell elements of the brain innate immune system within the PFC and hippocampus, and to unmask AT1-R? role in its development. Attention deficit was evaluated as a functional assessment of these brain areas.