AT1 receptors are essential players in the development of amphetamine-induced inflammation in prefrontal cortex: relevance for neuroinflammatory pathologies

OCCHIEPO V; MARCHESE NA; BREGONZIO C; BASMADJIAN M

Cordoba

Congreso; SAN 2018; 2018

Sociedad Argentina de Neurociencias

Amphetamines are related to brain vascular damage, neuroinflammation, working memory deficit and prefrontal cortex (PFC) hypo-function. Brain angiotensin II, through AT1 receptors (AT1-R), modulates catecholamine neurotransmission and is involved in psychostimulants-induced neuroadaptations. Furthermore, these receptors are key mediators in neuroinflammatory responses by promoting endothelial dysfunction, neuronal oxidative damage and astrocyte and microglial reactivity.Objectives. The present work aimed to elucidate amphetamine-induced changes in the cell elements of the brain innate immune system within the PFC and hippocampus, and to unmask AT1-R? role in its development. Attention deficit was evaluated as a functional assessment of these brain areas.