GLIAL METABOTROPIC GLUTAMATE RECEPTOR (mGlu3R) DYSFUNCTION IN ALZHEIMER´S: IMPLICATIONS FOR sAPPα-MEDIATED Aβ CLEARANCE

MARÍA JULIETA RUDI; JUAN TURATI; DELIA RAMIREZ; LILA CARNIGLIA; JULIETA SABA; CARLA CARUSO; JUAN BEAUQUIS; FLAVIA SARAVIA; MERCEDES LASAGA; DANIELA DURAND

Córdoba

Congreso; XXXIII Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2018

Sociedad Argentina de Investigación en Neurociencias

Astroglial mGlu3R promotes neuroprotective effects, such as releasing neurotrophin sAPPα and increasing Aβ uptake. We aimed to study whether mGlu3R alterations could be associated with AD progression in an AD mice model. Evidence for mechanisms involved in sAPPα-mediated Aβ elimination is provided here as well. mGlu3R protein levels remain stable during aging in non-transgenic (NTg) mice, whereas they progressively decrease with age in PDAPP-J20 (Tg) animals (p