Effect of systemic administration of mGlu3R agonist in a model of cerebral ischemia

JUAN TURATI; AMANDA NUNES SANTIAGO; DELIA RAMIREZ; LILA CARNIGLIA; JULIETA SABA; CARLA CARUSO; DANIELA DURAND; RÚBIA MARIA WEFFORT DE OLIVEIRA; MERCEDES LASAGA

Córdoba

Congreso; XXXIII Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2018

Sociedad Argentina de Investigación en Neurociencias

Chronic cerebral hypoperfusion (CCH) resembles central changes in aging-related vascular dementias and Alzheimer´s disease (AD). Our group has demonstrated, in vitro, that astroglial subtype 3 metabotropic glutamate receptors (mGlu3R) present protective actions against neurotoxic agents including Abeta. However, contradictory results were reported when mGlu3R ligands were administered in vivoWe examined the effect of the mGlu3R agonist, LY376298 (LY) 1mg/kg i.p., in middle aged rats with CCH. Memory retention was evaluated using the aversive radial maze and NeuN and GFAP expression were determined by immunohistochemistry.All groups showed increased latency and number of reference memory after surgery (p