ACTIVATION OF M1 PROFILE IN MACROPHAGES OF EPIDIDYMAL ADIPOSE TISSUE IS ASSOCIATED TO AN IMPAIRMENT IN ADIPOCYTE FUNCTION

GAMBARO, SABRINA ELIANA; ZUBIRÍA, MARÍA GUILLERMINA; MARIA AMANDA REY; MARTIN RUMBO; GIOVAMBATTISTA, ANDRÉS

Congreso; JOINT MEETING OF BIOSCIENCE SOCIETIES; 2017

Obesity has become one of the main public health problems and is usually related to unbalanced diet consumption and sedentary lifestyle. In Argentina, from 2005 to 2013 the prevalence of obesity has increased 42,5%, and is still growing. The aim of this study was to evaluate the innate immune function in adipose tissue (AT) of Swiss mice supplemented with a fructose rich diet (FRD) in drinking water (20%w/v) for 10weeks. Caloric intake and body weight were recorded every 48hs. Epididymal adipose tissue (EAT) was dissected and weighted at the end of the experiment and was processed for histology, qPCR and flow cytometry (FACS) analysis. FRD mice showed an increased in caloric intake (P