PERSONAL DE APOYO
DI SCIULLO Maria Paula
congresos y reuniones científicas
Título:
EXOSOMES ISOLATED FROM ASCITES OF T-CELL LYMPHOMA-BEARING MICE INDUCE A TUMOR-SPECIFIC IMMUNE RESPONSE
Autor/es:
FLORENCIA MENAY; FEDERICO COCOZZA; RODRIGO TSACALIAN; ANALIA ELISEI; LETICIA HERSCHLIK; JULIETA DE TORO; MARÍA JOSÉ GRAVISACO; MARÍA PAULA DI SCIULLO; ALEJANDRINA VENDRELL; CLAUDIA WALDNER; CLAUDIA MONGINI
Lugar:
Buenos Aires
Reunión:
Congreso; Reunion Conjunta de Sociedades de Biociencias; 2017
Resumen:
Exosomes are endosome-derived nanovesicles involved in cell?cell communication. Tumor exosomes can either activate or inhibit the immune system. The neoplastic stage and microenvironment can affect the quantity and composition of EVs determining their biological behavior. In this work, we have evaluated the ability of exosomes isolated from ascites of a murine T-cell lymphoma (ExoA) to modulate a tumor-specific immune response. ExoA induced in vitro proliferation of tumor sensitized splenocytes when compared with unstimulated control (p