INVESTIGADORES
DE MATTEO Elena NoemÍ
congresos y reuniones científicas
Título:
PEDIATRIC HODGKIN LYMPHOMA IN TWO SOUTH AMERICAN SERIES: A DISTINCTIVE
Autor/es:
MAGALHÃES BARROS MH; CHABAY P; HASSAN R; DAL LAGO A; DE MATTEO E; CARRICO MK; REY G; ZALCBERG I; PRECIADO MV
Lugar:
Colonia, Alemania
Reunión:
Simposio; 7th International Symposium on Hodgkin Lymphoma,; 2007
Institución organizadora:
European hematology Association
Resumen:
Hodgkin lymphoma (HL) shows a bimodal distribution with a first peak in developing countries during childhood. The causative role and prognostic significance of Epstein Barr virus (EBV) association in patients with HL is controversial. Our aim was to perform a comparative study of EBV association in two Latin American pediatric HL series, and to correlate it with patient's survival. EBERs in situ hibridization and LMP1 immunohistochemistry were performed on formalin-fixed paraffinembedded HL biopsies from 176 pediatric patients from 2 public institutions from Argentina and Southeast Brazil. All the patients received antracycline-based treatments. The median age of Argentine patients was 8 years (2-18) while in Brazilian patients was 14 years (3-18). MC subtype was prevalent in Argentine HL (52%), and NS subtype in Brazilian HL (83%). EBV expression was detected in 52% of cases, namely 54% Argentine HL and 48% Brazilian HL. EBV was significantly associated with MC subtype in both populations. In Argentine HL, EBV positivity was significantly higher in patients