Influence of pregnancy in the pharmacokinetics of intravenous cefquinome in goat

LITTERIO NICOLÁS JAVIER; LORENZUTTI AUGUSTO MATÍAS; HIMELFARB MARTÍN ALEJANDRO; ZARAZAGA MARÍA DEL PILAR; SAN ANDRÉS MANUEL IGNACIO; BOGGIO JUAN CARLOS

Tandil

Jornada; XL Reunión Anual de la Asociación Argentina de Farmacología Experimental; 2008

Asociación Argentina de Farmacología Experimental

Cefquinome (CFQ) is a fourth generation cephalosporin that was used in this study to assess its pharmacokinetics (PK) in pregnant goats, and their distribution to the fetus in the calving. Two groups of six Anglo Nubian goats were used; G1 with pregnant animals for four months, and G2 with non pregnant goat. All the animals were given CFQ (Cobactan® IV, 4.5%) at 2 mg/kg IV and were extracted blood between the 2 minutes to 48 hours postadministration. It was expected the birth in the G1 to administer CFQ at 2 mg/kg IV 30 minutes prior to a caesarean section, and take samples of maternal blood (pre-and postadministration), fetal blood (umbilical vein), amniotic fluid and placenta. Samples were analyzed by HPLC/uv. Pcnonlin 4.0 was used, by compartimental analysis. Results indicate that PK parameters of distribution and elimination in G2 were similar to happened in other species and significantly lower than that observed in G1 (Vd= 0.67±0.3 l/kg; T½β= 456±300 min; MRT= 675±450 min). Probably this is due to the hemodynamic changes, such as venous stasis by the presence of one or more fetuses, and the increased body water in maternal tissues that occurs in late pregnancy. Moreover, were not detected CFQ in fetal blood or amniotic fluid. The nature hydrophilic the CFQ limit his passage to the fetus, leaving circulating in maternal blood, for longer than non-pregnant females. This will have a positive effect on the antimicrobial therapy with CFQ in a pregnant goat.