Plasmatic disposition of florfenicol in goats

HIMELFARB MARTÍN ALEJANDRO; LORENZUTTI AUGUSTO MATÍAS; ERRECALDE CARLOS; PRIETTO GUSTAVO; LITTERIO NICOLÁS JAVIER; BOGGIO JUAN CARLOS

Tandil

Jornada; XL Reunión Anual de la Asociación Argentina de Farmacología Experimental; 2008

Asociación Argentina de Farmacología Experimental

This study has the objective to determine the relation milk/plasma of the florfenicol given by intravenous (IV), intramuscular (IM), and intramammary (IMM) routes in lactating goats. It has been performed a cross-over experimental design to the three routes of administration using 6 lactating goats. A single 20 mg/kg dose of Florfenicol (Microflud®, Vetanco, Bs. As., Argentina) was administered by the IV and IM routes, and 600 mg per mammary half for the IMM route. The plasma and milk samples were collected at regular intervals. Florfenicol was cuantified by HPLC. The data of plasmatic and milk concentration of florfenicol were analized on a non-compartimental model. The florfenicol demonstrated, by every routes, a very important diffusion, the concentration in milk, in relation to the plasma, is notable after the IV and IM administration, indicated by the high relation AUCmilk/AUCplasma, of 7,4 and 2,35 for these routes respectively. By the IMM route an important passage from milk to plasma was observed. In every routes of administration it was obtained higher milk concentrations than the MIC (minimium inhibitory concentration) for Staphylococcus aureus (0,5 ug/ml), the main mastitis causing pathogen, until 72 hs (for the IV and IM) and 120 hs for the IMM route.