Pharmacokinetic interaction between marbofloxacin and flunixin meglumine of dexamethasone after intravenous administration in goats

LORENZUTTI AUGUSTO MATÍAS; HIMELFARB MARTÍN ALEJANDRO; ZARAZAGA MARÍA DEL PILAR; AUAD JORDANA; BOGGIO JUAN CARLOS; LITTERIO NICOLÁS JAVIER

Rosario

Jornada; XLI Reunión Anual de la Sociedad Argentina de Farmacología Experimental; 2009

Sociedad Argentina de Farmacología Experimental

  The objective of this study is to determine a possible pharmacokinetic interaction between marbofloxacin (MFX) and flunixin meglumine (FM) or dexamethasone (DXM), respectively after intravenous administration in goats. 6 healthy goats were used, and a cross-over experimental design has been performed. The doses used were 5mg/Kg, 2 mg/Kg and 0.1 mg/Kg for MFX, FM and DXM, respectively. MFX and FM were administered intravenously and DXM intramuscularly. The blood samples were collected at regular intervals. MFX was quantified by HPLC. The data were analyzed by a bi-compartmental model. A wilcoxon test was performed. No differences were observed on the selected pharmacokinetics parameters between MFX and FM or MFX and DXM neither. Based in these results, we can conclude there is no pharmacokinetic interaction between MFX and FM or DXM, and changes in dosage regimen is not needed. However, more studies with different physiologic and pathologic states will be necessary.