Evaluation of anti-tumoral effect of hydroalcoholic blueberry extract against breast, colon and lung cancer cells.

ROCÍO SOLEDAD GARCÍA LÁZARO; HUMBERTO LAMDAN; NORAILYS LORENZO; LORENA CALIGIURI; DANIEL ALONSO; HERNÁN GABRIEL FARINA

Mar del Plata

Congreso; LXI Reunión Anual de la Sociedad Argentina de Investigación Clínica; 2016

Sociedad Argentina de Investigación Clínica (SAIC).

Blueberries belong to the Vaccinium genus. This fruit is characterized by a high amount of phytochemicals and antioxidants mainly represented by phenolic compounds. It was reported that these polyphenols can inhibit the growth and proliferation of tumor cells. In this work we evaluated the effect of a hydro-alcoholic blueberry- enriched polyphenols extract on the tumor progression steps in experimental models of breast (MDA-MB 231), colon (CT26) and lung (H125) cancer. The extract was able to inhibit the proliferation of CT26 and H125 cells with IC50 concentrations of 0.1 mg/L and 0.2 mg/L, respectively. Both, adhesion and migration of CT26 and MDA-MB 231 tumor cells were also modulated by the blueberry extract. The extract reduced by 60% the invasive ability of CT26 colon cancer cells. Latency, tumor growth and antiangiogenic capacity of the extract were studied using an in vivo model of Balb/C mice. Althought the results were not statistically significant, we observed a delay in latency and tumor growth and also a trend to reduced blood vessels, in blueberry extract-treated group. The results show that blueberry extract can modulate in vitro growth, adhesion and migration of tumor cells. The in vivo results encourage the search for management protocols that can maximize the anti-tumor potential of blueberries.