Cross-talk among different immunosuppressors factors in the generation of tumor immune escape

SALATINO M

Mar del Plata

Conferencia; SAIC 2009 Sociedad Argentina de Investigación Clinica; 2009

Compelling data support the view that immune system is important for the control of cancer development and growth. However, if both innate and adaptive immunity becomes impaired, tumor development occurs. It is widely documented that tumor cells employ mechanism that circumvent or usurp the immune response to enhance their own growth. These mechanisms include, among others, the secretion of immunosuppressive factors as galectin-1 and TGF-b1 and the recruitment of inhibitory cells as CD4+-CD25+-Foxp3+ regulatory T cells in the tumor microenvironment. Far from being straightforward these mechanism cooperate, interact and are subjected to the regulation of cytoquines, chemoquines and hormones tilting the balance to the generation of an immunosuppressive milieu. The knowledge and the dissection of these complex cross-talks between the immune system and the tumor will provide the fundamental basis to design a rational anticancer strategy aimed at blocking immunosuppressive signals the tumor microenvironment.