Tissue Engineering for Bone Reconstruction in Critical Size Defects: Hybrid Silk-Alendronate-Liposomes Interconnected Porous Scaffolds

V. E. BOSIO; D.S. GRAF CARIDE; E. BÉRTOLI; M. GALI

Munich

Congreso; Bone-Tec 2017 International Bone Tissue Engineering Congress; 2017

Tesnische Universitat Munchen, Trauma Lab & TERMIS

Bone loss caused by bone disease or fractures represents a challenge in the field in regenerative medicine, as regeneration depends on several factors, including cell?scaffold interactions (dependent on the biomaterial and biocompatibility, geometry, architecture, porosity, mechanical properties, degradation rate) or the presence of soluble molecules like cytokines, growth factors, hormones, ions, and vitamins to support osteogenic regulatory functions. This specific research consists of the study and development of a new platform for bone scaffolds for tissue engineering, to enhance the performance of known scaffolds in terms of mimicking the vascularized and mineralized structure of natural human bone.