INVESTIGADORES
GOREN Nora Beatriz
congresos y reuniones científicas
Título:
HP24, A NOVEL PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST: MOLECULAR MODELING AND SIGNALING PATHWAYS INVOLVED IN T. CRUZI-INFECTED MACROPHAGES
Autor/es:
FEDERICO NICOLÁS PENAS; CARTA, DAVIDE; CARLOS MODENUTTI; , GERARDO ARIEL MIRKIN; CEVEY AGATA; RADA, MARIA JIMENA; FERLIN, MARIA GRAZIA; MARIA ELENA SALES; GOREN, NORA
Lugar:
Buenos Aires
Reunión:
Congreso; Congreso de Sociedades de Biociencias; 2017
Institución organizadora:
SAIC SAI SAP SAIB
Resumen:
T. cruzi T. cruzi T. cruzi T. cruzi T. cruzi T. cruzi T. cruzi T. cruzi T. cruzi infection induces an intense inflammatory response indiverse host tissues. Upon parasite uptake, macrophages, whichare involved in the clearance of infection, increase inflammatorymediators, leading to parasite killing. However, exacerbation of theinflammatory response may lead to tissue damage. PPARγ is a ligand-dependentnuclear transcription factor that exerts importantanti-inflammatory effects.In this work we show for the first time, the mechanism of action ofa newly synthesized PPARγ ligand, pyridine carboxylic acid derivative(HP24) on macrophages (MΦ) from T. cruziT. cruziT. cruziT. cruziT. cruziT. cruziT. cruziT. cruzi-infected mice. Inorder to elucidate how HP24 interacts with PPARγ, virtual dockinganalysis was performed. Then, we evaluated the signaling pathwaysinvolved in the action of HP24, using NO release as a functional marker.T0070907 (T007), a specific PPARγ antagonist, partiallyrestored NO release by HP24-treated MΦ (P
