Hybrid biopolymeric matrices as molecular carriers

GUILLERMO R. CASTRO

Araraquara

Simposio; II International Symposium of Medicinal Chemistry and Regenerative Medicine; 2017

Universidad de Araraquara

Advances in micro- and nano-technologies are providing new ground for the development and characterization of biopolymeric hybrid matrices able to encapsulate/entrap and release unstable molecules under operational conditions. Cells can provide a myriad of molecules to be combined for a variety of useful applications. Among them, the powerful areas of diagnosis, monitoring, and treatment of pathologies through the use of drug delivery technologies are burgeoning. However, stability and release of biomolecules (i.e., proteins, enzymes) is a drawback and crucial point to overcome. Biopolymer matrices studied in our lab allow to bring stability and controlled release of some enzymes used for therapeutic purposes and antibiotics: a) gel microparticles made of alginate and pectins containing alginate lyase and fluoroquinolones were able controlled release the drug by the amount of alginate and the hydrolytic activity of the enzyme. In addition, the presence of alginate lyase in the matrix enhances the antimicrobial effect over biofilm made by P. aeruginosa, very useful in Cystic Fibrosis therapeutics. b) PVA films tailored with biopolymers can simultaneously release a keratinase and fluoroquinolone for the treatment of burns and skins wounds particularly useful in some chronic pathologies like diabetes and ulcerating wounds.