PERSONAL DE APOYO
MALDONADO Noelia Martina
congresos y reuniones científicas
Título:
Prior stress affects ZIF 268 expression after the retrieval of a contextual fear memory.
Autor/es:
ESPEJO, P.J.; MALDONADO, N.M; BUSTOS S.G; MOLINA, V.A.
Reunión:
Congreso; . XXVIII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias & Reunión Satelite/Neurobiología del comportamiento:Neuroetología y Neurobiología de la Memoria en el Cono Sur; 2013
Resumen:
It is well known that a fully consolidated memory canenter into a labile state after retrieval, requiring an additionalrestabilization process known as reconsolidation. However, there are boundary conditionsthat limit the occurrence of the labilization/reconsolidation process, forinstance, learning strength and memory age, among other factors. Previousstudies in our laboratory have shown that a stressful experience prior to a contextualfear conditioning procedure generates a memory that is resistant to the disruptiveeffect of Midazolam (MDZ) on reconsolidation. The goal of this study was toevaluate the influence of a previous stress experience on the expression of thetranscription factor zif 268 in the basolateral amygdala (BLA) after theretrieval of a fear memory. We observed that 90 minutes after reactivation, zif268 is enhanced in BLA in unstressed animals. In contrast, this increase wasnot evident in animals that were stressed before fear conditioning. Nodifferences were observed in non reactivated rats. This preliminary resultindicates that such molecular event suggested to be involved in the labilization/reconsolidationprocess is absent in stressed rats. This evidence agrees with the lack ofinterference on fear memory reconsolidation following MDZ administration in stressedanimals. Finally, we propose that the occurrence of a negative emotional stateat the moment of learning limits the subsequent emergence of the labilization/reconsolidationprocess.body {background: #FFFFFF;margin: 0px;padding: 0px;}