Corticoids Photodegradation in Homogenous and Micro-heterogeneous Media - Cytotoxicity of Photoproducts

CACCIARI, R. DANIEL; REYNOSO, EUGENIA; MONTEJANO, HERNÁN A.; BIASUTTI, M. ALICIA

Villa Carlos Paz - Córdoba

Congreso; XIII Encuentro Latinoamericano de Fotoquímica y Fotobiología; 2017

The use of biologically active substances with anti-inflammatory properties such as corticosteroidshas increased considerably in the last decades. Particularly, the compounds of our interest:Prednisolone (Predn), Prednisone (Pred) and Dexamethasone (Dx) belong to the family ofglucocorticoids (GC) most commonly used.Two aspects related to the interaction of the pharmaceuticals with light are of great interest. On theone hand the photostability of these compounds during their production and storage, and on theother hand their photodecomposition in less aggressive species to the environment when the drugsare removed, metabolized or not, throughout effluents. These GC absorb UV-B radiation and mayparticipate in photochemical processes, which can result in their own decomposition byunimolecular photodegradation or by the attack of reactive oxygen species (ROS) generated fromthe interaction of the GCs excited states with oxygen.In these sense, kinetic and mechanistic aspects of the direct photodegradation of GCs have beenstudied in aqueous and micro-heterogeneous medium under different atmospheric conditions bystationary and time-resolved techniques. Also, the cytotoxicity of the GCs and the photoproductsgenerated in different atmospheres were evaluated on model cell lines.