Conferencia plenaria

ALEJANDRO F. SCHINDER

Cancun

Congreso; Fusion Neurogenesis Conference, Implications for lifelong development and disease,; 2016

Remodeling dentate gyrus architecture and function by new granule cells The dentate gyrus of the hippocampus presents unique forms of plasticity conferred by the continuous generation of granule cells (GCs) that make millions of new connections every day. My lab has focused on understanding how new GCs change the preexisting circuits in a manner that might boost information processing. Over the years we have found that developing GCs are functionally relevant while they develop (before reaching maturity) due to a combination of intrinsic and network properties that make them hyperactive and highly susceptible to activity-dependent synaptic modification, distinct from all other neurons in the circuit. As a consequence, integration of new neurons in the network is also tailored by ongoing experience. In my talk I will dig into mechanisms that shape development, integration and function of new GCs and discuss their contribution to hippocampal function.