INVESTIGADORES
BERGUER Paula Mercedes
congresos y reuniones científicas
Título:
In vivo hemin pre-conditioning targets the vascular and immunological compartments and restrains prostate tumor development
Autor/es:
JAWORSKI, FELIPE; GENTILINI LUCAS; GUERON GERALDINE; MEISS ROBERTO; ORTIZ EMILIANO GERMÁN; BERGUER PAULA; AHMED ASIF; NAVONE NORA; RABINOVICH GABRIEL; COMPAGNO DANIEL; LADERACH DIEGO; VASQUEZ ELBA
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Conjunta 2016 entre la Sociedad Argentina de Investigación Clínica (SAIC), la Sociedad Argentina de Inmunología (SAI) y la Sociedad Argentina de Farmacología Experimental (SAFE); 2016
Institución organizadora:
SAI, SAIC, SAFE
Resumen:
?Pre-conditioning? strategies constitute a relatively unexplored and exciting opportunity to shape tumorfate. In this study we used hemin, an inducer of Heme Oxygenase-1 (HO-1), in an in vivo preconditioningmodel to assess prostate cancer (PCa) development. The stroma of immunocompetentC57BL/6 mice (n=5) was conditioned by subcutaneous administration of hemin prior to TRAMP-C1(murine PCa cell line TC1) tumor challenge. Pre-conditioning resulted in increased tumor latency anddecreased initial growth rate (P
