LPS INDUCES CYCLOOXYGENASE 2 EXPRESSION IN Y1 ADRENAL CELLS: INVOLVEMENT OF PI3K/AKT AND P38 MAPK SIGNALING PATHWAYS

MERCAU, MARÍA ELISA; GIORDANINO, ELIAN; ASTORT, FRANCISCO; BENFATTO, NICOLAS; OLEJARCZYK, JUAN M.; COSO, OMAR; CYMERYNG, CORA BEATRIZ

BARILOCHE

Simposio; THE SECOND SOUTH AMERICAN SPRING SYMPOSIUM IN SIGNAL TRANSDUCTION AND MOLECULAR MEDICINE; 2012

Previous studies from our laboratory have shown that LPS treatment stimulates adrenal steroid synthesis in Y1 cells by a mechanism involving NFkB-dependent COX-2 induction. Present experiments were designed to analyze the involvement of p38 MAPK and PI3K/AkT signaling cascades in this effect. An increase in p38 MAPK and Akt phosphorylation was observed 30 minutes after the initiation of LPS treatment (p