Changes in the antioxidant status of brain structures in a rat model of glaucoma.

FERREIRA, SM; ; REIDES, CG; ; LASAGNI VITAR, RM; ; LERNER, SF; ; LLESUY, SF.

Congreso; Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO).; 2015

Changes in the antioxidant status of brain structures in a rat model of glaucoma.Sandra M Ferreira; Claudia Gabriela Reides; Romina Mayra Lasagni Vitar; Ricardo Brunzini; Fabian S Lerner; Susana Llesuy Author Affiliations & NotesInvestigative Ophthalmology & Visual Science June 2015, Vol.56, 3671. doi:AbstractPurpose: Glaucoma is usually considered as an eye disease, but also damages structures in the brain. The goals of this study were to establish the antioxidant status of brain visual structures in an experimental rat model of glaucoma and to evaluate the possible protective role of lipoic acid in oxidative damage.Methods: Episcleral venous occlusion model in rats (Wistar, 3 months age) was used. Rats were divided in four groups (n=24): glaucoma (G), glaucoma treated with lipoic acid 50 mg/kg i.p. (LG), control received a sham procedure (C), control treated with lipoic acid 50 mg/kg i.p. (LC). 7 days after surgery rats were euthanized. Brains were removed and lateral geniculate nucleous and visual cortex (left and right) were separated. These parameters were evaluated: thioredoxin reductase (TR), glutathione peroxidase (GPx), lipidperoxidation markers (TBARS), non-enzymatic antioxidants (TRAP). One-way ANOVA and a post hoc Tukey test were used.Results: TR diminished 37% in left cortex (p