INVESTIGADORES
ROSSO Silvana Beatriz
congresos y reuniones científicas
Título:
Wnt-Fz signaling regulates dendrite architecture through the co-activation of CaMKII and JNK pathways.
Autor/es:
FERRARI, MARÍA EDITH; ROSSO SILVANA
Lugar:
Mar del Plata
Reunión:
Congreso; XXX Congreso Anual de la SAN; 2015
Institución organizadora:
Sociedad Argentina de Investigaciones en Neurociencia
Resumen:
In the nervous system, key processes such neuronal polarization and migration, axon pathfinding, dendrite morphogenesis and synapse formation are regulated by morphogens, among which Wnt proteins stand out. They bind to transmembrane receptors Frizzled (Fz) and also interact with tyrosine kinase receptors, such as Ryk, Ror, and IGF-1R. After the Wnt-receptor interaction, at least three different signalling pathways may be activated: Wnt/β-catenin (canonical pathway), planar cell polarity (PCP) and Calcium pathways (non canonical pathways). Previously, we observed that Wnt7b-Fz7 affected the architecture of dendrites in hippocampal neurons. To go further, we analyzed the contribution of specific effectors of PCP and Calcium non-canonical pathways and observed that Wnt7b induced the activation of both CaMKII and JNK in Fz7 expressing neurons. In the present work, we link morphological changes in dendritic arborization to CaMKII and JNK activation. Moreover, we analyze a possible co-activation between the non-canonical pathways.