INVESTIGADORES
CONDAT Carlos Alberto
congresos y reuniones científicas
Título:
Spatio-temporal evolution model for competitive ligand inding
Autor/es:
C.A. CONDAT; P.P. DELSANTO; G. PEREGO; E. RUFFINO
Lugar:
Boston, MA (EE.UU.)
Reunión:
Conferencia; "Fall Meeting", Materials Research Society; 1997
Institución organizadora:
Materials Research Society
Resumen:
Ligand binding is an essential step in many biological and biochemical processes, notably protein activation. In many cases, the binding rates are determined by competition blockers competing with ligands or decoys competing with receptors. Often, the diffusivities of the various species also play a key role. The usual modeling of these processes, however, either involves well-mixed systems, for which spatial variations are neglected, or steady-state situations for which all time evolution has ceased. The model presented here can instead account for the spatial variations that originate as a consequence of inhomogeneous initial conditions and localized binding sites. It describes their evolution due to a combination of mechanisms of diffusion, competition, and reaction. The model, which is formulated in terms of a coupled system of equations, for the probability densities of the various populations, is easy to adapt to different specific conditions and is particularly well suited for numerical calculations, e.g., on a parallel computer. Since it yields concrete predictions, it can be readily used to predict the concentrations and distributions of the various species that are needed to obtain prescribed responses.