NEUROTROPHIN RECEPTORS EXPRESSION IN CAIMAN LATIROSTRIS THYMUS

GAUNA AÑASCO, LG.; DI MATTEO, AM.; SOÑEZ, MC.; GAZZANEO, P.; LOMBARDO, DM.

Buenos Aires

Jornada; Primer Encuentro Rioplatense De Biologia - XIV Jornadas Anuales De La Sociedad Argentina De Biología. Fundación Pablo Cassará,; 2012

SOCIEDAD ARGENTINA DE BIOLOGÍA. SOCIEDAD URUGUAYA DE BIOCIENCIAS

Neurotrophins (NTs) are growth factors that act in nervous system and also in lymphatic system of domestic animals. The objective of this work was to determine the location of high affinity receptors for NTs in thymus of Caiman latirostris compared with other domestic and wild animals (Astianux fasciatus, pigeon, broiler chicken, Chaetoprhactus vellerosus, pig, cow, horse, Lama glama and human. 14 thymuses were fixed in 10% buffered formalin and processed with histological routine technique, embedded in parafin. On serial sections an indirect immunocytochemical method (ABC) was applied using anti-TrkA, B and C, diluted 1:100. In the negative controls primary antibody incubation was omitted. TrkA expressed in type VI reticular epithelial cells as in Astianux fasciatus, broiler chicken, Chaetophractus sp, pig, cow, Lama glama and human. TrkB was identified in dendritic cells of the cortico-medullary region as in pigeon. TrkC was localized in type VI reticular epithelial cells as in Astianux fasciatus and Chaetoprhactus sp. As in other vertebrate species, NTs receptors were identified in the thymus cythoreticulum cells, suggesting a possible paracrine role of NGF (TrkA), BDNF (TrkB)