INVESTIGADORES
MONCLUS Maria De Los Angeles
congresos y reuniones científicas
Título:
EFFECT OF OLIVE OIL INTAKE ON CHOLESTEROL METABOLISM IN HYPERCHOLESTEROLEMIC RABBITS
Autor/es:
SIMÓN L; FOURNIERF; ROMERO AIDA A; FUNES A.K.; JAKOVCEVIC D; YAPUR MARCHANT M; BOARELLI P.V; MONCLUS M.A; CAYADO N; CABRILLANA M.E; VINCENTI A.E; SAEZ LANCELLOTTI TANIA ESTEFANÍA; FORNÉS M.W
Lugar:
Valdivia
Reunión:
Otro; XXIV Reunión Anual Sociedad Chilena de Reproducción 2013. Reproducción y Desarrollo: Desde la Fisiología a la Patología con la Mirada en el Futuro.; 2013
Institución organizadora:
Sociedad Chilena de Reproducción y Desarrollo
Resumen:
Olive oil (OO)
the principal fat of Mediterranean Diet, is known to benefit hypercholesterolemia
(HC), a recognized risk factor of cardiovascular disease. Recently, HC has also
been associated with poor semen/sperm quality that may lead to male
infertility. We have previously found that Hypercholesterolemic rabbits (HCR)
have poor semen/sperm quality, and OO supplementation improved sperm physiology
and semen parameters affected by high saturated fat cosumption. Our interest
resides in studing at molecular levels the intracellular pathway of cholesterol
metabolism in testes, in order to find
out the cause that ultimately led to altered semen parameters and its reversión
by OO intake. Twenty New Zeland Rabbits were randomly distributed in
experimental groups: NCR (normal cholesterol rabbits),
HCR (developed by feeding a high fat diet: 0,05% Cholesterol), and protected
group (developed by addition of 7% OO concomitant with the HC diet for 16
weeks). Study period lasted 12 months. We found that saturated or unsaturated lipid intake, affects differently the intracelular pathway of
cholesterol metabolism. Specifically, a transcription factor, SREBP, changed
its expression (RNAm and protein) depending on the type of fat consumed,showing
a putative molecular mechanism for OO protection, Our data demonstrated that OO improves semen quality in our rabbits model of HC, and
suggest that the mechanism acounting for this protective effect likely involves
complex alterations in cellular metabolism beyond simply reduction in cholesterol.