INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
congresos y reuniones científicas
Título:
Development of a retrieval-induced forgetting paradigm in rodents to model adaptive forgetting in the mammalian brain.
Autor/es:
FRANCISCO GALLO; FACUNDO MORICI; MAGDALENA MIRANDA; NOELIA WEISSTAUB; PEDRO BEKINSCHTEIN
Lugar:
Huerta Grande
Reunión:
Congreso; XXIX Congreso de la Sociedad Argentina de Neurociencias.; 2014
Institución organizadora:
Sociedad Argentina de investigación en Neurociencias
Resumen:
Over a
century of research has presumed that forgetting reflects passive mechanisms such
as decay and interference. In the last two decades, however, a growing human
literature on retrieval-induced forgetting (RIF) has pointed to inhibitory
control processes that resolve retrieval competition as a cause of adaptive
forgetting. However, the lack of animal-based models for RIF has precluded the
understanding of the neurobiological mechanisms. Using spontaneous recognition
memory in rats, we have successfully developed a rodent paradigm for RIF. We
were able to show that forgetting of an item associated with a particular
context happens under conditions that cause competition between memory traces
for two items that share a particular retrieval cue. Forgetting is long lasting
and independent of the selected retrieval cue and it is controlled, in rats, by
the medial Prefrontal Cortex (mPFC), homologue to the Dorsolateral Prefrontal
region in humans. Our results provide evidence that adaptive forgetting occurs
in non-human animals and that homologue regions are required for it. These
results suggest that this type of forgetting is achieved by top down inhibition
exerted by mPFC over the brain structures that store the memory traces.