INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
congresos y reuniones científicas
Título:
Arc is required for pattern separation across the spatial and the object domains in the dentate gyrus and perirhinal cortex
Autor/es:
MAGDALENA MIRANDA; FACUNDO MORICI; NOELIA WEISSTAUB; PEDRO BEKINSCHTEIN
Lugar:
Huerta Grande
Reunión:
Congreso; .XXIX Congreso de la Sociedad Argentina de Neurociencias.; 2014
Institución organizadora:
Sociedad Argentina de investigación en Neurociencias
Resumen:
Successful
memory involves not only remembering information over time but also keeping
memories distinct and less confusable. The ability to separate the components
of memories into distinct memory representations relies on pattern separation,
a computational process by which differences are amplified to disambiguate
similar events. Despite the importance of this mnemonic function, the molecular
mechanisms and signals necessary for the behavioral manifestations of this
process remain unknown. Although pattern separation has been localized to the
dentate gyrus of the hippocampus and shown to occur in a spatial domain, this
cognitive function is thought to take place also during processing of other
types of information. The perirhinal cortex (PRH) is involved in the
acquisition and storage of object memories. Thus, we hypothesized that this
structure is involved in pattern separation of object memories. In this work,
we used both a hippocampal-dependent and a PRH-dependent task and manipulated
the load of pattern separation during information encoding. We showed that
acquisition/ consolidation of pattern-separated memories depend on the
expression of Arc on both tasks, and that interaction between Arc and BDNF
pathways is necessary for successful pattern separation. These findings suggest
that Arc, an immediate early gene known to regulate synaptic plasticity and
mediate memory formation, is involved in the molecular mechanisms underlying
pattern separation.