INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
congresos y reuniones científicas
Título:
Persistence of a fear motivated memory is dependent on hippocampal protein synthesis during a
Autor/es:
PEDRO BEKINSCHTEIN; LIONEL MÜLLER IGAZ; IVAN IZQUIERDO; MARTÍN CAMMAROTA; JORGE H. MEDINA
Lugar:
Innsbruck, Austria
Reunión:
Congreso; ISN ESN 20th BIENNIAL MEETING; 2005
Institución organizadora:
International Society for Neurochemistry-European Society for Neurochemistry
Resumen:
To
the present time, memory research has been extensively and successfully devoted
to the study of the mechanisms and brain circuits involved in long term memory
formation. It is widely accepted that consolidation for several learning
tasks is dependent upon hippocampal de novo protein synthesis. In this
sense, it has been demonstrated that many learning tasks, including Inhibitory
Avoidance (IA), require de novo protein synthesis during the first 6 hr
after acquisition. However, the role of early hippocampal protein synthesis in
memory persistence has never been addressed. Intra-hippocampal inhibition of
protein synthesis by anisomycin caused amnesia for IA learning in a 7-day
retention test, but not in a 2-day retention test in a time-dependent manner. A
learning-dependent increase in the level of five hippocampal proteins that peaked
at 24 hr was detected by immunoblot. Anisomycin infusion that caused a memory
deficit at 7 days, prevented c-Fos, Homer-1a and Akt increases at 24 hr. Our
results reveal that early and time-restricted protein synthesis in rat
hippocampus is required after acquisition for persistence, but not formation of
IA memory. This hippocampal mechanism for memory persistence may involve c-Fos
and Homer-1a expression around 24 hr after acquisition.