An endocrine system scaling method for healthy rats and humans

GERMÁN CAMPETELLI; LAUTARO BRACCIA; MERCEDES LOMBARTE; MARTA BASUALDO; ALFREDO RIGALLI

Congreso; VII CAIQ 2013 y 2das JASP; 2013

As a common laboratory practice rats are studied as biological models for understanding several human?s diseases. However, only few works propose a methodology for quantifying the analogies between both species. This work presents a systematic procedure to construct efficient models to predict more accurately what would happen in human beings based on the experimental results obtained from rats. In this context, the well-known model of healthy subjects given by Sorensen et al. (1985) was adequate to implement the scale-up methodology based on some assumptions given by Hall et al. (2012). Therefore, the main contribution of this work is to present the detailed scale-up procedure which needed to do an extensive search on the literature to adapt the human model to the rat model. It is expected that this validated rats model could be useful for testing diets, physical exercises effects, drugs delivery, pharmacokinetics studies for then extrapolate conclusions for human beings.