Present status of Accelerator-Based BNCT

A.J. KREINER; J. BERGUEIRO; M. BALDO; D. CARTELLI; W. CASTELL; J. GÓMEZ; J. PADULO; J.C. SUAREZ SANDIN; M. IGARZABAL; J. ERHARDT; D.O. MERCURI; D.M. MINSKY; A.A. VALDA; J.M. KESQUE; M.E. CAPOULAT; M.S. HERRERA; S. GONZÁLEZ; H. SOMACAL; M.E. DEBRAY; M.F. DEL GROSSO; L. GAGUETTI; M. SUÁREZ ANZORENA; N. CANEPA; N. REAL; N. GUN; H. TACCA; L. ROGULICH

Granada

Congreso; 7th Young Researchers Boron Neutron Capture Meeting; 2013

Universidad de Granada

Presentación oral Accelerator-Based BNCT (AB-BNCT) is establishing itself worldwide as the future modality to start the phase of in-hospital facilities. There are projects in Israel, Italy, Japan, Russia, UK and Argentina to develop AB-BNCT around different types of accelerators. They will be mentioned and compared. In particular, the present status and recent progress of the Argentine project [1] will be presented. The topics will cover: accelerator prototypes under development and construction, transport of intense beams, beam diagnostics, high power targets, the 9Be(d,n) reaction as a possible neutron source, treatment planning assessment of clinical cases, etc. A complete 200 kV accelerator prototype has been built and results will be shown. A 600 kV prototype is under construction. An ion source test stand has been built and commissioned for intense proton beam production and characterization. Beam diagnostics has been performed through the observation of induced fluorescence in the residual gas. Selfconsistent space charge beam transport simulations have been performed and compared with experimental results. In addition to the traditional 7Li(p,n)7Be reaction, 9Be(d,n)10B using a thin Be target has been thoroughly studied as a candidate for a possible neutron source for deep seated tumors, showing a satisfactory performance [2]. Results on Be-based neutron production targets will be briefly mentioned [3]. Realistic clinical treatment planning cases for 7Li(p,n)7Be?based AB-BNCT have also been studied showing very good results [4].     [1] A J Kreiner, W Castell, H Di Paolo, M Baldo, J Bergueiro, A A Burlon, D Cartelli, V Thatar Vento, J M Kesque, J Erhardt, J C Ilardo, A A Valda, M E Debray, H R Somacal, J C Suarez Sandin, M Igarzabal, H Huck, L Estrada, M Repetto, M Obligado, J Padulo, D M Minsky, M Herrera, S J Gonzalez and M E Capoulat, ?Development of a Tandem-Electrostatic- Quadrupole facility for Accelerator-Based Boron Neutron Capture Therapy?, Appl. Radiat. Isotopes 69, (12)1672?1675 (2011) and references therein. [2] E Capoulat, D M Minsky and A J Kreiner, ?Computational assessment of deep-seated tumor treatment capability of the 9Be(d,n)10B reaction for Accelerator-Based Boron Neutron Capture Therapy (AB-BNCT)?, Physica Medica, EJMP-D-13-00018R2 (2013). [3] M Suarez Anzorena, L Gagetti, M F del Grosso and A J Kreiner, ?Caracterizacion de depositos de Be sobre sustratos de Mo, W y Cu para implementar un blanco de producción de neutrones para AB-BNCT?, 13 Congreso Internacional de Ciencia y Tecnología de Metalurgia y Materiales, en prensa (2013). [4] M Herrera, S Gonzalez, D M Minsky, A J Kreiner, ?Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets?, Physica Medica (Europ. Journal Medical Physics), 272, DOI information: 10.1016/j.ejmp.2013.01.006.