INVESTIGADORES
DICKENSTEIN Alicia Marcela
congresos y reuniones científicas
Título:
Computational algebraic geometry and biochemical reaction networks.
Autor/es:
A DICKENSTEIN
Lugar:
Guanajuato
Reunión:
Congreso; Mathematical Congress of the Americas 2013; 2013
Institución organizadora:
UMALCA - AMS
Resumen:
In recent years, techniques from computational algebraic geometry have
been successfully used to address mathematical challenges in systems biology.
(Bio)chemical reaction networks define systems of ordinary differential
equations with (in general, unknown) parameters. Under mass-action kinetics,
these equations depend polynomially on the concentrations of the chemical
species. Biologically-relevant steady states correspond thus to the positive
real solutions of a structured system of polynomial equations. The
nonlinearities usually prevent a mathematical analysis of network behaviour,
which has largely been studied by numerical simulation and lacks a more comprehensive
study of the dependence on the parameters.
The algebraic theory of chemical reaction systems aims to understand
their dynamic behavior by taking advantage of the inherent algebraic structure
in the kinetic equations, and does not need
a priori determination of the parameters, which can be practically and
theoretically impossible. I will present a gentle introduction to the basic
concepts and main questions, together with applications to enzymatic
mechanisms.