“Insulin enhances leptin expression in human trophoblastic cells”

ANTONIO PÉREZ-PÉREZ; YÉSICA GAMBINO; JULIETA MAYMÓ; PILAR GUÁDIX; JOSÉ LUIS DUEÑAS; CECILIA VARONE; VICTOR SÁNCHEZ MARGALET

Foz de Iguazú

Congreso; VI Simposio Latinoamericano: Interacción Materno-fetal y Placenta.; 2013

SLIMP

Leptin, the adipokine that controls energy metabolism, acting in the central nervous system, and with pleiotropic peripheral effects, acting as a proinflammatory cytokine, is also produced by trophoblastic cells in placenta, where leptin seems to function as a trophic autocrine hormone. Expression of leptin has been shown to be high in placenta, mainly, in placenta of gestational diabetes mellitus (GDM) pregnancies, which correlates with increased circulating leptin plasma levels. It has been reported that leptin is regulated by various, partially tissue specific factors, however, the complete regulation of leptin production in the placenta is still poorly understood. That is why, we investigated it expression and the regulation by insulin in JEG-3 trophoblastic cells and human placental from normal pregnancies.