A preliminary comparative study of CaTiO3 prepared by different methods

ANDREA P. RODRIGUEZ; RYO TAMAMURA; SILVIA S. BORKOSKY; MIHO INOUE; HIDETSUGU TSUJIGIWA; HITOSHI NAGATSUKA; GULSAN ARA SATHI; ETSUO KISHIMOTO; MASARU AKAO; NORIYUKI NAGAI

Tokushima

Congreso; The 17th Annual Meeting of the Society for Hard Tissue Regenerative Biology; 2008

Tokushima Bunri University

Titanium and its alloys have been widely used as biomedical and dental materials because of their excellent biocompatibility and good mechanical properties. However, one disadvantage of these materials is that it takes long time to obtain good fixation between the material and living bone. Improvement of bone conductivity of these materials is demanded from biomedical field such as orthopedics and dentistry. In order to enhance the ability of these materials, various bioactive coatings on their surface have been attempted. Recently, calcium titanate (CaTiO3) and carbon-coating materials have taken much attention in research for biomedical applications. For that reason, we developed a novel material called "calcium titanate-amorphous carbon" (CaTiO3-aC) prepared by alkoxide (CaTiO3-aC alko) and modified thermal decomposition (CaTiO3-aC mtd) methods. In this study, the objective was to evaluate the crystallinity and carbon amount of the particles, and to compare the effect of different CaTiO3 materials on cell response using bone marrow stromal cells. Thus, the results indicated that CaTiO3-aC alko and CaTiO3-aC mtd exhibited peaks corresponding to perovskite-type CaTiO3 peaks. The amount of deposited carbon in CaTiO3-aC alko and CaTiO3-aC mtd particles were higher (5-9% and 4.3% respectively) than the commercial CaTiO3 particles (0.8%). Moreover, CaTiO3-aC alko and CaTiO3-aC mtd enhanced the cell response compared with commercially-prepared CaTiO3. The obtained results indicate that the amount of C could play a key role in the cell response of calcium titanate materials. In conclusion, our findings suggest that CaTiO3-aC alko plays a more dominant effect on cell response compared with the others, which could be considered as an important biomaterial for medical application.