Effect of CaTiO3-aC coating material by thermal decomposition method on osteoblastic cell response

HIROYUKI MATSUDA; MIHO INOUE; ANDREA P. RODRIGUEZ; SILVIA S. BORKOSKY; RYO TAMAMURA; MASAHISA INOUE; TOHRU TAKAGI; SHIN TAKAGI; MASARU AKAO; NORIYUKI NAGAI

Tokushima

Congreso; The 17th Annual Meeting of the Society for Hard Tissue Regenerative Biology; 2008

Tokushima Bunri University

HA-coated titanium implants have excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak, because of the lack of chemical interaction between HA and titanium. A solution to this problem is to form an intermediate film on titanium substrate. Because of this, we have developed a novel biomaterial called Calcium Titanium Oxide-Amorphous Carbon (CaTiO3-aC; patent: 2005-269868; 2005-269869). The purpose of this study was the identification of cellular proliferation and differentiation of osteogenic cells. Osteoblastic cell line MC3T3-E1 was cultured on CaTiO3-aC and HA coating plates. CaTiO3-aC had high cellular proliferation and differentiation compared to HA. In conclusion, we suggested that CaTiO3-aC could be considered an important candidate not only as an intermediate film but also as a coating material.