Disease modifying immunotherapy for the management of autoimmune diabetes

PERONE, MJ

Buenos Aires

Simposio; III Iberoamerican Congress on NeuroImmunoModulation; 2009

Type 1 diabetes (T1D) is a T cell-mediated autoimmune diseasethat destroys the insulin-secreting  -cells of the pancreas.It is now possible to predict those candidates that willprogress to T1D before the full onset of the disease. Preventionof uncontrollable autoimmunity against  -cells in therapiesfor T1D is mandatory to preserve the  -cell mass.Therefore, immunomodulatory strategies directed to inhibitingthe activity of self-reactive T cell clones as well as inductionof regulatory T cells would be beneficial for preventionof T1D or recurrence of  -cell autoimmunity against islet cellallografts.