IMBALANCE OF MESIAL SYNCHRONIZATION IN TEMPORAL LOBE EPILEPSY

GUILLERMO ORTEGA; JESÚS PASTOR; RAFAEL GARCÍA DE SOLA

Roma

Congreso; 29th International Epilepsy Congress; 2011

ILAE

Purpose: Temporal lobe epilepsy is commonly associated with synchronous,hypersynchronous and desynchronous activity. The aim of the present work is to explore synchronization activity in both mesial areas in temporal lobe epileptic patients during the interictal state Method: Using a cluster technique, we analyzed 17 temporal lobe epilepsy patients’ records of foramen ovale electrodes activity during the interictal state. Results: There exists a clear tendency in the mesial area of the epileptic side to be organized as isolated clusters of electrical activity as compared with the contralateral side, which is organized in the form of large clusters of synchronous activity. The number of desynchronized areas is larger in the epileptic side than in the contralateral side in 16 out of 17 temporal lobe epileptic patients. Conclusion: The mesial area responsible for the seizures is less synchronous than the contralateral; the different kind of synchronous organizationaccounts for a lower synchronization activity at the epileptic side, suggesting that this lack of synchronous cluster organization would favor the appearance of seizures. Our results shed new light regarding synchronization issues in temporal lobe epilepsy and also it would help in reducing drastically the lateralization time.