INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
congresos y reuniones científicas
Título:
Role of mPFC 5-HT2a receptors in the resolution of memory interference during retrieval
Autor/es:
MARIA RENNER; PEDRO BEKINSCHTEIN; NOELIA WEISSTAUB
Reunión:
Congreso; Reunion Annual de la Sociedad Argentina de Neurociencias; 2011
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Role of mPFC
5-HT2a receptors in the resolution of memory interference during retrieval.
Maria Renner,
Pedro Bekinschtein, Noelia V Weisstaub.
The medial Pre Frontal Cortex
(mPFC) has been involved in complex integration of information necessary during
response selection and interference. The interference theory refers to the idea
that forgetting occurs because the recall of certain items interferes with that
of other items. Thus, the retrieval of two memory traces that share certain
neuronal circuits will activate the PFC to prevent interference resulting in
the forgetting or suppression of one of the traces in favor of the other one.
The
mPFC is modulated by many neurotransmitter systems including the serotonergic
system. Serotonin (5-HT) acts through 14 different receptors. In the mPFC one
of the most important one is the 5-HT2a receptor. It is not clear which is the
role of the serotonergic system in memory interference processes. In this work
we evaluate the role of mPFC 5-HT2a receptors in memory interference using
different versions of the spontaneous object recognition task in rats. We found
that blockage of mPFC 5-HT2a receptors 15 minutes before retrieval alter the
response in the temporal order and object in context tasks. We also evaluate
the specificity of the blockage of 5-HT2a receptors. We found that blockage of
5-HT2a but not 5-HT2C receptors affect the ability of the cortex to avoid
memory interference and that activation
of 5-HT1A receptors produce behavioral responses similar to the blockage of
5-HT2a. We also investigate if there were a biochemical correlate to the
behavioral effects observed finding that the behavioral deficits observe after
5-HT2a blockage in the mPFC correlates with an increase expression of immediate
early genes in the perirhinal cortex.