INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
congresos y reuniones científicas
Título:
Role of mPFC 5-HT2a receptors in the resolution of memory interference during retrieval
Autor/es:
MARIA RENNER; PEDRO BEKINSCHTEIN; NOELIA WEISSTAUB
Reunión:
Congreso; Reunion Annual de la Sociedad Argentina de Neurociencias; 2011
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Role of mPFC 5-HT2a receptors in the resolution of memory interference during retrieval. Maria Renner, Pedro Bekinschtein, Noelia V Weisstaub.  The medial Pre Frontal Cortex (mPFC) has been involved in complex integration of information necessary during response selection and interference. The interference theory refers to the idea that forgetting occurs because the recall of certain items interferes with that of other items. Thus, the retrieval of two memory traces that share certain neuronal circuits will activate the PFC to prevent interference resulting in the forgetting or suppression of one of the traces in favor of the other one. The mPFC is modulated by many neurotransmitter systems including the serotonergic system. Serotonin (5-HT) acts through 14 different receptors. In the mPFC one of the most important one is the 5-HT2a receptor. It is not clear which is the role of the serotonergic system in memory interference processes. In this work we evaluate the role of mPFC 5-HT2a receptors in memory interference using different versions of the spontaneous object recognition task in rats. We found that blockage of mPFC 5-HT2a receptors 15 minutes before retrieval alter the response in the temporal order and object in context tasks. We also evaluate the specificity of the blockage of 5-HT2a receptors. We found that blockage of 5-HT2a but not 5-HT2C receptors affect the ability of the cortex to avoid memory interference and  that activation of 5-HT1A receptors produce behavioral responses similar to the blockage of 5-HT2a. We also investigate if there were a biochemical correlate to the behavioral effects observed finding that the behavioral deficits observe after 5-HT2a blockage in the mPFC correlates with an increase expression of immediate early genes in the perirhinal cortex.