Aging alters biochemical and molecular basis of memory, in the rat temporal cortex

DEYURKA, NICOLÁS; LACOSTE, MARÍA GABRIELA; ANZULOVICH, ANA CECILIA

San Luis

Congreso; XXXVIII Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias.; 2023

Sociedad Argentina de Investigación en Neurosciencias

Aging is a progressive, accumulative and deleterious process occurring in most living species. The temporal cortex (TC) is one of the neocortical association areas that underlies the long-term storage of declarative memory and it is particularly affected by aging. Here, we studied how aging affects the biochemical and molecular basis of memory, in the TC of male Holtzman rats. For this purpose, we analyzed BMAL1 and RORa protein levels, Bdnf, Rc3 and Nrf2 mRNA levels, CAT and GPx expression and enzymatic activity, and lipid peroxidation levels, in the TC of 3- and 22-mo-old rats. An IBM SPSS Box-Plot analysis showed no variation in BMAL1 and RORa protein levels nor CAT antioxidant activity, decreased GPx expression and activity (p