Exploring the antiproliferative potential of the ethyl acetate extract from Coleus neochilus

VALLADARES TAMARA; MAYORA JUSTEL CARLA LUCIANA; ALZA NATALIA; LÜTHY ISABEL ALICIA; ESANDI MARÍA DEL CARMEN; BRUZZONE ARIANA

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias 2023 (SAIC-SAB-AAFE-AACyTAL); 2024

SAIC-SAB-AAFE-AACyTAL

EXPLORING THE ANTIPROLIFERATIVE POTENTIAL OF THE ETHYL ACETATE EXTRACT FROM COLEUS NEOCHILUSTamara Valladares1, Carla Luciana Mayora Justel1,2, Natalia Alza1, Isabel Lüthy3, María del Carmen Esandi1,2 and Ariana Bruzzone21 Instituto de Investigaciones Bioquímicas Bahía Blanca-CONICET, 2 Departamento de Biología Bioquímica y Farmacia - UNS, 3 Instituto de Biología y Medicina Experimental-CONICETColeus species have diverse ethnobotanical uses, most of them related to their medicinal properties. Previously, we described the antiproliferative effect of the ethanolic extract of Coleus neochilus (also known as boldo rastrero). This study focused on the effect of one of the subfractions of the ethanolic extract, the ethyl acetate fraction (BRAE), on human breast cancer cells. Four different fractions were obtained from the original ethanolic extract by using different solvents: hexane, chloroform, ethyl acetate and methanol-water. Incubation with BRAE 25 μg/ml reduced cell viability in MCF-7, T47-D, and MDA-MB-231 tumor cells (35%, 21% and 8% reduction, respectively; p